Bone-graft substitutes in orthopaedic surgery

By A. Alex Jahangir, MD; Ryan M. Nunley, MD; Samir Mehta, MD; Alok Sharan, MD; and the Washington Health Policy Fellows

As the number of products increases, patient safety must remain a top concern

Bone grafting is a big business, generating sales of more than $2.5 billion a year.1 Of the more than 3 million musculoskeletal procedures done annually in the United States, about half involve bone grafting with either an autograft or an allograft.2 Worldwide, autografts or allografts are used in approximately 2.2 million orthopaedic procedures annually.3

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