Narrowing the focus on aseptic loosening

By Jay D. Lenn

OREF grant recipient examines role of mononuclear cells

Aseptic loosening, the most common cause of long-term failure in hip and knee replacements, occurs when normal wear on a prosthetic joint produces microscopic debris particles that trigger an immune system response. This immunologic activity mediates osteolysis, which loosens the bond between the implant and bone.

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