On the genetic frontier: Idiopathic scoliosis

Scoliosis is derived from the Greek “skoleosis,” which means “a crookedness.” But for orthopaedic surgeons specializing in this challenging disease, scoliosis is often far more than a simple crookedness. The use of growing rods, titanium ribs, and advanced surgical techniques has helped thousands, but researchers continue to look for ways to advance the science.

The AAOS has endorsed an information statement on scoliosis screening in schools (see article here). And recently, AAOS Now senior science writer Annie Hayashi sat down with James W. Ogilvie, MD, past president of the Scoliosis Research Society (SRS); Nancy H. Miller, MD, Johns Hopkins University; Carol Wise, PhD, Texas Scottish Rite Hospital for Children; and Alain Moreau, PhD, head of the molecular genetics lab for musculoskeletal diseases at the Ste-Justine University Hospital Centre, Montréal, Canada, to discuss the present state of the science and what can be expected in the future.

Ms. Hayashi: How would you describe the present state of the science of identifying genes associated with idiopathic scoliosis (IS)?

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