BMPs and cancer: Is the risk real?

By Steven Gitelis, MD; Ross M. Wilkins, MD; and Alan W. Yasko, MD

The FDA requires warnings, but the science isn’t definite

Implant-related carcinogenesis has been a concern for orthopaedic surgeons for many years. Extensive work has been done with metals and metal alloys commonly used in orthopaedics, but no convincing evidence of a causal relationship has been found. Although isolated case reports of carcinogenesis have been reported, most surgeons feel confident using modern metallic and plastic implants.

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