Update: PRP in Orthopaedics

By Barbara D. Boyan, PhD

Platelet rich plasma (PRP) has been used clinically since the 1970s. Recent advances in methods for PRP preparation and use have made it possible for surgeons to take advantage of this concentrated form of growth factors and cytokines that are naturally present in blood clots.

The concept is attractive because the patient’s own blood is used, limiting the potential for disease transmission. This is also a major limitation to the predictability of PRP as a therapeutic modality. The composition of PRP varies from patient to patient and may also vary with the device used to prepare it, the time and method of storage until it is used, and whether it is used or interacts with other biologics or materials.

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