Bisphosphonates: the good, the bad, and the unidentified

By Corey O. Montgomery, MD; John W. Bracey, MD; and Larry J. Suva, PhD

Bisphosphonates (BPs) are chemically stable analogues of inorganic pyrophosphate. Studies on the role of inorganic pyrophosphate in the control of soft-tissue and skeletal mineralization resulted in the discovery that these compounds could inhibit calcification. This realization triggered additional studies to determine whether these compounds could inhibit other physiologic processes, such as bone resorption.

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