Studies probe Wnt pathway as target for osteosarcoma therapy

By Terry Stanton

Kappa Delta Ann Doner Vaughan Award recognizes efforts to develop novel treatments

Osteosarcoma is an aggressive disease that has a high propensity for local invasion and early distant metastasis (Fig. 1). Aggressive treatment protocols, including chemotherapy and wide surgical resection, can achieve cure in approximately 60 percent to 70 percent of patients, primarily adolescents and young adults. Yet the 5-year survival rate for patients with relapse is only 20 percent, and this number has not changed significantly over the last two decades.

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