Protein profiling for periprosthetic joint infection

By Jennie McKee

Molecular markers may enable easier and more accurate diagnosis of periprosthetic joint infection (PJI), according to the results of a study presented by Javad Parvizi, MD, FRCS, at the 2011 AAOS Annual Meeting.

Because currently available tests for PJI are costly, cumbersome, and lack specificity regarding whether component failure is septic or aseptic, Dr. Parvizi and his fellow researchers used biomarker immunoassays to “investigate the role that protein profiling might play in improving the ability to diagnose PJI quickly and accurately.”

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