The Clinic–Lab–Clinic Loop in Understanding BMPs

OREF grant recipient looks for ways to enhance healing effect of BMPs

Sally T. Halderman

The body depends on complex biologic checks and balances, and activating one molecular pathway toward a therapeutic goal may trigger feedback loops that dampen the effect. Jaimo Ahn, MD, PhD, an orthopaedic trauma surgeon as well as a cell and molecular biologist, wondered whether a feedback loop might be one factor limiting the effectiveness of bone morphogenetic proteins (BMPs) in accelerating bone healing.

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