Can Muscle Atrophy Be Reversed?

OREF grant recipient studies biology of muscle loss in massive rotator cuff tears

Jay D. Lenn

Surgical repair of small rotator cuff tears is a common procedure, and patients usually do quite well. However, repairing large, massive rotator cuff tears is more challenging and outcomes are not as predictable. Large tears have a higher rate of recurrence and lower function even after successful repair. These problems are due, in part, to injury-related remodeling of the muscle, including irreversible muscle atrophy and fatty infiltration of muscle tissue. Also, massive tears may result in nerve damage that can exacerbate muscle degeneration.

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