The Importance of Clinical Significance in AAOS CPGs

David S. Jevsevar, MD, MBA

The main goal of clinical orthopaedic research is determining how to best treat patients. Studies are designed to answer the following questions: Do patients improve with a particular intervention? Or do the results indicate that the intervention makes things worse—even to the point of inflicting harm to the patient?

Improvement is measured by many outcomes, including decreased pain, better function, and enhanced quality of life. In determining whether a particular intervention is beneficial, studies that compare the treatment to a placebo are preferred whenever possible. The research gold standard is randomized controlled trials because they can eliminate spurious confounding and biases that might lead to faulty results for the treatment of interest.

This content is only available to members of the AAOS.

Please log in using the link at the top right corner of this page to access your exclusive AAOS member content.

Not a member? Become a member!