From Limb Deficiency to (Re)Generation

OREF grant recipient seeks to understand the origin of congenital limb deficiencies

Catherine Rategan

Limb deficiencies are among the most common and disabling of all congenital anomalies. Many conditions, such as tibial hemimelia, involve the femur and anterior structures such as the tibia (Fig.1) and the great toe. The genetic root of most of these anomalies is still unknown and the embryologic basis by which the affected limb elements develop normally is scarcely understood.

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