Using Biomarkers to Diagnose Periprosthetic Joint Infection

Study finds testing synovial fluid may be a promising approach

Terry Stanton

The diagnosis of periprosthetic joint infection (PJI) remains a clinical challenge. It currently requires an algorithmic approach using a varied assortment of clinical and laboratory considerations. Considering the substantial harm that PJI causes—in accounting for 25 percent of failed knee arthroplasties and 15 percent of failed hip arthroplasties—an improvement in diagnostic capability would provide an appreciable benefit to patient health as well as serve to blunt the economic impact of this complication.

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