Taking a Second Look at Effectiveness of Viscosupplementation

Blinded studies show far lower efficacy than unblinded studies

  When the AAOS first issued a clinical practice guideline (CPG) on nonarthroplasty treatment of knee osteoarthritis (OA) in 2009, the evidence on the effectiveness of viscosupplementation (hyaluronic acid [HA] injections) as a treatment option was inconclusive. When the CPG was reviewed and reissued in 2013, the evidence—according to the work group—was undeniable: "We cannot recommend using hyaluronic acid for patients with symptomatic osteoarthritis of the knee," they wrote.

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