Peripheral Nerve Sheath Tumors

Abstract

Peripheral nerve sheath tumors (PNSTs) are soft-tissue tumors that arise from the supportive elements of the peripheral nerves. Benign PNSTs, including neurofibromas and schwannomas, typically present as painless, slow-growing masses. MRI is an important component of the evaluation of these tumors. Neurofibromas and schwannomas have distinct histologic features and show characteristic immunohistochemical staining. Different variants of these tumors have histologic features that distinguish them from one another. Benign PNSTs are treated by surgical excision. Although certain general principles apply to the surgical treatment of all benign PNSTs, modified surgical techniques are required for each type.

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