Surgical site infection (SSI) is the infection of superficial or deep tissue at the surgical site that occurs up to 30 days after surgery or up to 1 year after surgery in patients with instrumentation. Deep SSIs often require irrigation and débridement to eradicate the infection in the operating room. Multiple case series have been published to support use of negative pressure wound therapy (NPWT) in deep SSI when primary closure cannot be achieved at index surgery. Research has shown NPWT to reduce the complexity of wound closure; decrease the number of dressing changes and débridements before definitive closure; increase the ease of exposure for subsequent irrigation and débridement; remove interstitial fluid and promote blood flow for healing; and decrease bacterial wound colonization, especially in regions with high contamination rates such as the lower back. The specific technique of NPWT in exposed dura has been poorly described in spine surgery.