Prevention of Surgical Site Infections after Major Extremity Trauma

Clinical Practice Guideline

Published March 21, 2022

The scope of this guideline includes preoperative, perioperative, and postoperative interventions in addition to an evaluation of risk factors to decrease surgical site infection following major extremity trauma. This guideline does not provide recommendations for patients with a current surgical site infection at the site of orthopaedic trauma, for patients undergoing secondary surgeries (i.e., non-union or malunion), or for patients with
injuries isolated to their fingers or toes.


Clinical practice guidelines (CPG) provide evidence-based recommendations for current orthopaedic diagnostic, treatment, and postoperative procedures. Multdisciplinary clinician work groups and AAOS staff work together to synthesize published research with the aim of providing a transparent and robust summary of the research findings for a particular orthopaedic disease topic.

Trauma ToolKit

The Trauma Toolkit is a collection of information, resources, and tools to assist AAOS members in making informed practice decisions based on evidence-based recommendations and/or practice standards. The information provided compiles advocacy, practice management, and quality improvement resources while including clinical and patient education.