The AAOS Orthobiologics Registry (OBR) is a disease and condition-focused registry designed to measure the long-term safety, efficacy, and real-world outcomes of orthobiologic therapies for patients diagnosed with knee osteoarthritis. The pilot program will begin with 10 participating sites, with plans for methodical expansion over the next three to five years.

The Registry will focus on patient-reported outcomes and longitudinal tracking, with unique attributes including:

• Research-focused registry design with patient consent
• Centralized follow-up for patient-reported outcome measures (PROMs) completion
• Linkage to the BARB Biorepository for biological sample analysis
• Integration with standardized hemoanalyzer configuration
• Detailed adherence protocol to ensure high-quality data collection

OBR Participation

While participation in the OBR is not open currently, AAOS is looking forward to sharing findings that emerge from Registry analyses.