Megan Depalma

Orthopaedic Surgeon: Kristy L. Weber, MD, FAAOS

Hospital: Hospital of the University of Pennsylvania

Megan was diagnosed with sarcoma at age 23. She was told by doctors that she would need to have her leg amputated. However, orthopaedic surgeon Kristy L. Weber, MD, FAAOS, at Penn Medicine was able to remove her tumor and reconstructive and microsurgery surgeon Stephen J. Kovach, III, MD, was able to reconstruct her leg. Today, she is able to walk, run, and live her life the way she wanted.

To view Megan’s story, click here.



Early on after my diagnosis, I decided that I wasn't going to sacrifice my future because of cancer. Instead, I chose to focus on the life that I wanted when the journey was over. Everyday, I put one foot in front of the other knowing that it was a step closer to the milestones I always dreamed about. Since the last time you saw me, I have been busy enjoying the moments that pushed me through my treatment and recovery. Marrying my husband, watching my son experience the beach for the first time and giving back to Penn Medicine really feel like full circle moments and I know that without Dr. Weber and her team I wouldn't be where I am today.

From the moment Dr. Weber and I met, I knew that she was going to be more than a doctor. She has become my advocate, my cheerleader, the steadying voice on the other end of the phone when my mind wanders. She has become family. Together, with our Sarcoma committee, we have raised awareness and hundreds of thousands of dollars for Sarcoma Research at Penn Medicine. I feel so lucky every day that my path led me to Dr. Weber and Penn.


AAOS and MSTS Care About Sarcoma Patients

The AAOS Registry Program has developed the Musculoskeletal Tumor Registry (MsTR) with support from the Musculoskeletal Tumor Society (MSTS), and this July, and throughout the year, the work that occurs through the collection, analysis, and dissemination of Registry data supports the improvement of sarcoma patient care.

For more information about this Registry, visit

To make a donation, visit here.